Methylation at SLC6A4 is linked to family history of child abuse: an examination of the Iowa Adoptee sample.

نویسندگان

  • Steven R H Beach
  • Gene H Brody
  • Alexandre A Todorov
  • Tracy D Gunter
  • Robert A Philibert
چکیده

Methylation at SLC6A4 Is Linked to Family History of Child Abuse: An Examination of the Iowa Adoptee Sample Steven R.H. Beach,* Gene H. Brody, Alexandre A. Todorov, Tracy D. Gunter, and Robert A. Philibert University of Georgia, Athens, GA Department of Psychiatry, Washington University, St. Louis, MO Department of Neurology and Psychiatry, St. Louis University School of Medicine, St. Louis, MO Department of Psychiatry, The University of Iowa, Iowa City, IA Neuroscience and Genetics Programs, The University of Iowa, Iowa City, IA

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منابع مشابه

Effects of Genotype and Child Abuse on DNA Methylation and Gene Expression at the Serotonin Transporter

Altered regulation of the serotonin transporter (SLC6A4) is hypothesized to be a key event in many forms of neuropsychiatric illness, yet our understanding of the molecular mechanisms through which changes in gene function could lead to illness remains incomplete. In prior studies, we and others have demonstrated that methylation of CpG residues in the promoter associated CpG island alters SLC6...

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Introduction: Child abuse includes abuse of the body, mental and sexual abuse or misbehavior against children that leads to damage to the child's heath and comfort. Therefore, the present study was done in order to determine the prevalence of child abuse in opiate addicts referring to addiction withdrawal centers. Methods: The cross sectional study included 300 participations (150 addicts and ...

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Impact of child sex abuse on adult psychopathology: a genetically and epigenetically informed investigation.

Genetic, environmental, and epigenetic influences and their transactions were examined in a sample of 155 women from the Iowa adoptee sample who had been removed from their biological parents shortly after birth and assessed when participants were an average of 41.10 years old. We observed an interactive effect of child sex abuse (CSA) and biological parent psychopathology (i.e., genetic load) ...

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عنوان ژورنال:
  • American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics

دوره 153B 2  شماره 

صفحات  -

تاریخ انتشار 2010